European Antibiotic Awareness Day is taking place on 18 November 2021. For this occasion, ANSES is publishing the results of several monitoring programmes that it carries out to prevent the emergence and spread of antibiotic-resistant bacteria in farm and domestic animals in France. Below is a review of some key findings with Jean-Yves Madec, Scientific Director for antimicrobial resistance and Head of the French surveillance network for antimicrobial resistance in pathogenic bacteria of animal origin (RESAPATH), Gérard Moulin, Deputy Director of the French Agency for Veterinary Medicinal Products (ANMV), and Agnès Perrin-Guyomard, Deputy Head of the National Reference Laboratory for antimicrobial resistance.